Ikhithi Yokuhlola ye-Allergen-specific IgE (Izingxenye)

Izifo ezingezwani nomzimba yizimo lapho isiguli sihogela khona noma sidle izinto eziqukethe izakhi ezingezwani nomzimba (okuthiwa izinto ezingezwani nomzimba noma izinto ezingezwani nomzimba, izinto ezingezwani nomzimba) ezibangela amaseli B omzimba ukuthi akhiqize i-immunoglobulin E (IgE) eyeqile.Lapho amasosha omzimba e-IgE evezwa kabusha ezintweni ezingezwani ne-vivo, axhumanisa nezinto ezingezwani nomzimba futhi abophe i-FcεRI ephezulu ye-affinity receptor ebusweni bama-mast cells nama-basophil, okuholela ekuqongeleleni kwe-FcεRI kanye nokusebenza kwe-mast cell kanye ne-basophil.Ngesikhathi sokusebenza, amangqamuzana e-mast adiliza futhi akhulule i-histamine, umlamuleli ovuthayo ogcinwe kuma-cytoplasmic granules, kanye ne-leukotrienes, i-immunoreactive prostaglandin, ama-cytokines nama-chemokines anjenge-IL-4 ne-IL-5 ahlanganiswe ngendlela ye-arachidonic acid, eqala izimpawu zesifo sokungezwani komzimba ( ukungezwani komzimba nezinye izifo), njengesifuba somoya esingezwani nomzimba, i-hay fever, i-urticaria, i-rhinitis engezwani ne-eczema, i-allergic dermatitis, i-conjunctivitis kanye nokungasebenzi kahle kwe-gastrointestinal.Ukunqunywa kwamasosha omzimba ahambisana ne-allergen-specific IgE ku-serum kungasetshenziswa ukusiza ekuxilongweni kwezinto ezibangela ukungezwani komzimba emisebenzini yomtholampilo futhi kukhethwe uhlobo olufanele lwe-immunotherapy lweziguli.

Ukuhlolwa kwengxenye ye-allergen kuyindlela entsha yokuxilongwa kwezifo ezibangelwa ukungezwani komzimba, futhi ngokusekelwe ekutholeni i-IgE ethile.Ngokungafani nokukhishwa kwe-allergen engahluziwe esetshenziswa ezindleleni zokuxilonga zendabuko, ukuxilongwa kwengxenye yokucacisa kusebenzisa ukungezwani komzimba okuhlanjululwe kwemvelo/okuphinda kuhlanganiswe i-monomer ukuze kubonakale ama-molecule athile abangela ukungezwani komzimba, okwenza ukutholakala kwezifo eziguliswayo kube nembe kakhulu.Ingakwazi ukuxilonga ngokunembile ukuthi yiziphi izinhlobo zamaphrotheni angezwani nesiguli isiguli futhi siguliswa kangakanani, ngaleyo ndlela inikeze isisekelo sokwelashwa okwengeziwe komuntu ngamunye.Ukusetshenziswa kwale ngxenye yeprotheyini ye-allergenic njenge-reagent yokwelapha i-desensitization kugwema imiphumela emibi engase ibangelwe yizingxenyana zamaprotheni ezingezona i-allergenic noma izingxenye ezingezona amaprotheni ze-allergenic extracts.Ukutholwa kwengxenye ye-Allergen kungase kuhlonze izingxenye zamaprotheni ezizwela ngempela ezintweni ezingezwani nomzimba, kuxazulule izinkinga zokuxilonga eziqondene ne-allergen ethile ebangelwa ukusabela okuphambene, futhi kuqinisekise ukunemba nokusebenza kokutholwa kwesifo sokungezwani komzimba.Le ndlela ingasiqonda kahle isimo sokusabela kwe-allergen futhi ibikezele ezinye izinto ezingase zingezwani nazo.