Ikhithi Yokuhlola Ubungozi Benhliziyo

Ukuhlolwa kwengozi ephelele yesifo senhliziyo (i-CVD) kusekelwe ezingeni lezici ezihlukahlukene zobungozi zesifo senhliziyo futhi kuhlanganiswe ukwahlulela noma ukubikezela umuntu noma iqembu labantu esikhathini esizayo eminyakeni emihlanu, iminyaka eyishumi noma okunye. Impilo yami enesifo esiyingozi senhliziyo nemithambo yegazi (i-acute myocardial infarction, ukufa okungazelelwe kwesifo senhliziyo kanye nokunye ukufa kwe-coronary, kanye ne-acute cerebral apoplexy) okungenzeka, Ukugcizelelwa okuyinhloko kusekwehlulelweni noma ekubikezelweni kwengozi yesikhathi esizayo ye-ischemic. isifo senhliziyo esisekelwe ku-atherosclerosis (ASCVD).

I-Apolipoprotein iyingxenye yamaprotheni e-plasma lipoprotein, engabopha futhi ihambise i-lipids yegazi ezicutshini ezihlukahlukene zomzimba ukuze i-metabolism futhi isetshenziswe.Inani elikhulu lezifundo lithole ukuthi ukuguqulwa kofuzo lwe-apolipoprotein kuholela ekwakhekeni kwe-allelic polymorphisms ehlukene kanye nokuqhubeka nokwakhiwa kwama-phenotypes ahlukene we-apolipoprotein, angathinta imetabolism kanye nokusetshenziswa kwe-lipids yegazi, ngaleyo ndlela kuthinte ukwenzeka nokuthuthukiswa kwe-hyperlipidemia, i-atherosulinosis, izifo zenhliziyo kanye ne-cerebrovascular, njll.

I-ApoA1 iyisakhi esikhulu kunazo zonke se-ApoA kanye ne-apolipoprotein eyinhloko ku-HDL.I-ApoA1 ephansi ijwayelekile ku-atherosclerosis.

I-Apolipoprotein B ikhona phezu kwe-low density lipoprotein.Ukuqashelwa kwamaseli nokuthathwa kwe-LDL kutholwa ngokuyinhloko ngokuqashelwa kwe-apolipoprotein B.Ngakho-ke, lapho i-apolipoprotein B inyuka, ngisho noma izinga le-LDL livamile, lingandisa futhi izehlakalo zesifo senhliziyo.

I-Lipoprotein A yenziwa ngokuyinhloko esibindini.Ukukhuphuka okuqhubekayo kwezinga le-lipoprotein kuhlobene eduze ne-angina pectoris, i-myocardial infarction kanye nokuphuma kwegazi ebuchosheni, futhi kuyisici esizimele sengozi yokushaywa unhlangothi nesifo senhliziyo.

Ucwaningo luye lwabonisa ukuthi ezigulini esezikhulile ezine-acute cerebral infarction, iziguli ezine-CRP ephakeme zine-prognosis embi.Okuqukethwe kwe-Hs-crp kuhlobene nosayizi we-infarct kanye nezinga lokukhubazeka kwemizwa, futhi ingenye yezinkomba zedigri ye-lesion yeziguli ze-cerebral infarction.Ngaphezu kwalokho, i-CRP iphinde ihileleke enqubweni ye-pathological ye-thrombosis kanye ne-arteriosclerosis, futhi ingenye yezinto eziyingozi zokushaywa yisifo sohlangothi.