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imikhiqizo

Ikhithi Yokuhlola Yesistimu Yezinzwa Emaphakathi Ye-Demyelination IgG

Central Nervous System Demyelination Antibodies IgG Test Kit Featured Image
  • Central Nervous System Demyelination Antibodies IgG Test Kit

incazelo emfushane:

Isifo se-central nervous system demyelinating (CNSDD) yisifo esizimele esibonakala nge-multifocaality kanye ne-inflammatory demyelination ye-central nervous system (CNS).


  • Intengo ye-FOB:US $0.5 - 9,999 / Ucezu
  • Inani elincane le-oda:100 Isiqephu/Izingcezu
  • Ikhono Lokuhlinzeka:10000 Ucezu/Izingcezu Ngenyanga

    • Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Isixazululo se-Chemiluminescent (i-Autoimmune Diseases)

    Uchungechunge

    Igama Lomkhiqizo

    Abbr

    I-Central Nervous System Demyelination Antibodies IgG

    I-Central Nervous System Aquaporin 4

    I-AQP4

    I-Myelin Oligodendrocyte Glycoprotein

    I-MOG

    I-Myelin Basic Protein

    I-MBP

    I-AQP4 iyisithuthi esikhethekile samanzi esitholakala ikakhulukazi kuma-astrocyte e-CNS, kodwa futhi ezinso (umgudu wokuqoqa), amaphaphu (amaseli e-bronchial epithelial), isisu (amangqamuzana e-gastric parietal), i-epithelia yezindlala ehlukahlukene kanye nemisipha yamathambo.I-AQP4, isiteshi samanzi esichichima kakhulu ku-CNS, iyi-homotetramer ebambelele phezu kwama-astrocyte ngephrotheni ye-dystroglycan.Phakathi kwazo zonke izifo eziqeda ukuvuvukala ze-CNS, i-AQP4 iyisinqumo sokuqala sokuhlukanisa i-NMO ne-MS kwezinye izifo ezivuthayo (okucacisiwe> 95%).Njengoba ama-MRIs ekhanda leziguli ane-NMO yakuqala ngokuvamile engaphawuleki, ukuhlolwa kwe-serological kwe-AQP4 kungaba usizo ekuqondiseni ukwelashwa nokubikezela kusenesikhathi.Izinga elihle le-AQP4 lalingama-40% ezigulini ezine-longitudinally extensive transverse myelitis (LETM) kanye nama-20% ezigulini ezine-optic neuritis (ON).Ezigulini ezine-clinical alobar syndrome (ON noma LETM), i-positivity ye-AQP4 iphakamisa cishe amathuba angama-50% okuthuthukisa i-CNS demyelination phakathi nonyaka ongu-1.

    Izifo ze-MOG antibody ziye zavela kancane kancane ezindaweni zabantu eminyakeni yamuva.I-MOG (i-myelin oligodendrocyte glycoprotein) iyi-glycoprotein enesisindo samangqamuzana asuka ku-26 kuya ku-28 kDa.Ivezwa ngokuqondile ezingqimbeni ze-myelin ezingaphandle kanye nama-oligodendrocyte ezilwane ezincelisayo ku-CNS futhi ikhombisa izinga eliphezulu lokongiwa kuzo zonke izinhlobo zezilwane, lapho ingasebenza njengophawu lokuvuthwa kwe-oligodendrocyte futhi ihileleke emisebenzini ehlukahlukene yebhayoloji njengokulawula ukuqina kwe-microtubule, umzila ohambisanayo we-classical.Ekuqaleni, abacwaningi bahlonze i-MOG njengethagethi yokunciphisa ukuzivikela komzimba kumodeli ye-guinea pig ye-experimental autoimmune encephalomyelitis (EAE).

    I-MBP itholwa ku-serum noma i-CSF yeziguli ze-MS, kodwa lokho akuchazi ukuthi lawa ma-autoantibodies ahileleke ngokuqondile ku-pathogenesis yokulimala kwe-MS demyelinating noma akhiqizwa kuphela ngemva kokulimala kwezicubu ezihambisana ne-CNS.Kuyacaca ukuthi i-antibody ezigulini ze-MS ingakwazi ukuhlukanisa ama-polypeptide e-MBP futhi ibangele ukulimala kwe-myelin, futhi lawa masosha omzimba we-myelin, ikakhulukazi ohlobo lwe-IgG1, angenza kusebenze umphelelisi, enze i-cytotoxicity encike kumaseli encike ku-antibody.

     

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