Ikhithi Yokuhlola I-Clotting Factor Plasma Reagent
| Isixazululo se-Coagulation | ||
| Uchungechunge | Igama Lomkhiqizo | Abbr |
| I-Clotting Factor Plasma Reagent | I-Clotting Factor II-Deficient Plasma | F II |
| I-Clotting FactorV-Deficient Plasma | FV | |
| I-Clotting Factor VII -I-Plasma Engenayo | F VII | |
| I-Clotting Factor X-Deficient Plasma | FX | |
| I-Clotting Factor VIII -I-Plasma Engenayo | F VIII | |
| I-Clotting Factor IX-Deficient Plasma | F IX | |
| I-Clotting Factor XI-Deficient Plasma | F XI | |
| I-Clotting Factor XII-Deficient Plasma | F XII | |
| I-Berichrom FXIII | F XIII | |
Izinto eziningi zokujiyisa zatholwa ekuqaleni njengama-ejenti angasebenzi kahle kuma-plasma eziguli ezingavamile ezinezinkinga zofuzo ze-coagulation.Phakathi neminyaka yawo-1940 kuya ko-1960, izici eziningi zaqanjwa abaphenyi abahlukene ngemva kwegama lesiguli esasintula isici esisha.Kunezici ezihlukahlukene zokujiyisa ezikhona egazini, ezithwala ukujiya kwehlule futhi ukopha kakhulu kungase kubangele ukuntuleka kokujiyisa.
Izici zokuhlanganisa ziqokwa ngezinombolo zesi-Roman kanje: I-Factor XII, i-Factor XI, i-Factor IX, i-Factor VIII, i-Factor X, i-Factor V ne-Factor II Factor VII ne-FXIII.Izici zokujiyisa ezicushiwe ziqokwa ngesijobelelo esithi “a,” isb, FVIIIa, FIXa.Izici zokujiya zonke zikhiqizwa ku-hepatocyte yesibindi.
Ukutholwa kwezinto zokuhlangana manje kungafinyelelwa ngokunqunywa kokuqukethwe kwe-plasma fibrinogen (FIB), i-plasma factor VIII, IX, XI kanye ne-XII procoagulant assay, i-plasma factor II, V, VII kanye ne-X procoagulant assay, i-plasma factor Factor XIII Qualitative Test. kanye ne-Plasma Factor XIII Subunit Antigen Determination.
I-herited coagulation factor deficiency disorders.Ibonakala ngezimpawu zokopha njalo kusukela ebuntwaneni, kanye nomlando womndeni wefa.Ngaphandle kwe-hemophilia A no-B, okuyifa le-chromosomal recessive yobulili, ngokuvamile ifa eliphindaphindiwe le-autosomal.Kokubili abesilisa nabesifazane bangathinteka, futhi kuvame ukuba nomlando wokuganana.Izifo ezikuleli qembu zonke ziwukuntuleka kwesici esisodwa se-coagulation, lapho ukuntuleka kwe-factor VIII (i-hemophilia A) kuvame kakhulu, futhi zonke ezinye izici ngaphandle kwe-III kanye ne-IV zingashoda.
Isifo sokuntuleka kwe-coagulation factor.Zonke zishoda ngezinto eziningi futhi zinezifo eziyinhloko.Ezivamile ezifana nokuntuleka kwe-vitamin K ukuntula kwe-factor II, VII, IX, ne-X, kanye nesifo esibi kakhulu sesibindi.Ukuxilongwa kuwukuhlola amaphethini oku-coagulation nokulungisa izivivinyo.Ukwelashwa nge-plasma entsha noma i-cryoprecipitate kusebenza kahle, futhi ezigulini ezitholiwe, isifo esiyinhloko kufanele selashwe.
Ucwaningo oluningi lukholelwa ukuthi umsebenzi we-coagulation factor II ujwayelekile noma wehla kancane ezigulini ezine-hepatitis eyingozi kanye ne-hepatitis engapheli;ezigulini ezinokulinganisela, ezinzima ze-hepatitis engapheli kanye ne-cirrhosis, izinga lomsebenzi we-coagulation factor II lehla kakhulu, okubonisa ukuthi izinga lokunciphisa kwalo lihlobene namaseli esibindi.
Umsebenzi we-coagulation factor V wehliswa kuphela lapho umsebenzi wesibindi uncishisiwe noma isifo sesibindi esinzima, ngakho-ke kubhekwa njengenkomba enhle yokwahlulela ukubikezelwa kweziguli ezinesifo sesibindi.
I-coagulation factor VII ine-half-life emfushane kakhulu (4 ~ 6h), futhi okuqukethwe kwe-plasma kuphansi (0.5 ~ 2mg / L), ngakho-ke ingasetshenziswa njengenkomba yokuqala yokuxilonga yokungasebenzi kahle kwe-protein synthesis ezigulini ezinesifo sesibindi.
