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imikhiqizo

I-Fibrinolytic System & DIC Test Kit

incazelo emfushane:

Uhlelo lwe-fibrinolytic luyingxenye ebalulekile yesistimu yokuhlangana futhi ludlala indima ebalulekile ekugcineni uketshezi lwegazi kanye nobuqotho bemithambo. I-activator ye-Lysogen kanye ne-fibrinolysis inhibitor.Inqubo eyisisekelo ye-fibrinolysis ingahlukaniswa izigaba ezimbili, okungukuthi ukusebenza kwe-plasminogen kanye nokuwohloka kwe-fibrin (noma i-fibrinogen).


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Isixazululo se-Coagulation

Uchungechunge

Igama Lomkhiqizo

Abbr

I-Fibrinolytic System & DIC

Imikhiqizo Yokuwohloka kwe-Fibrinogen

I-FDP

I-D-Dimer

I-D-Dimer

I-Plasminogen

I-PLG

I-α2-antiplasminase

α2-AP

I-Plasminogen Activation Inhibitor

PAI

I-Von Willebrand Factor Antigen

I-vW Factor Antigen

Uhlelo lwe-fibrinolytic luyingxenye ebalulekile yesistimu yokuhlangana futhi ludlala indima ebalulekile ekugcineni uketshezi lwegazi kanye nobuqotho bemithambo. I-activator ye-Lysogen kanye ne-fibrinolysis inhibitor.Inqubo eyisisekelo ye-fibrinolysis ingahlukaniswa izigaba ezimbili, okungukuthi ukusebenza kwe-plasminogen kanye nokuwohloka kwe-fibrin (noma i-fibrinogen)

I-Plasminogen (PLG): I-PLG ihlanganiswa yisibindi.Uma igazi lijiya, i-PLG ikhangiswa kuwebhu ye-fibrin ngobuningi.Ngaphansi kwesenzo se-T-PA noma i-U-PA, i-PLG yenziwa isebenze ibe yi-plasminase, ekhuthaza ukuqedwa kwe-fibrin.I-Plasminogen iyiketango elilodwa i-β -globulin enesisindo se-molecule engu-80000 ~ 90000. Ihlanganiswa esibindini, emnkantsheni, e-eosinophils, nasezinso bese ingena egazini.Kubantu abadala, 10-20 mg/100ml we-plasma.Ine-half-life egazini lezinsuku ezi-2 kuya kwezi-2.5.Ikhangiswa kalula ku-substrate yayo, i-fibrin.

I-Plasminogen activator inhibitor (PAI) kanye ne-α2 anti-plasminogen inhibitor (α2-AP).I-PAI ingabophezela ngokuqondile ku-T-PA ngesilinganiso esingu-1:1 ukuze iyenze isebenze futhi yenze i-PLG isebenze.Amafomu amakhulu yi-PAI-1 kanye ne-PAI-2.I-α2-AP ihlanganiswa yisibindi.Indlela yokusebenza imi kanje: I-α2-AP ibophezela ku-PL ngesilinganiso esingu-1:1 ukuze yakhe inkimbinkimbi, evimbela umsebenzi we-PL.U-F ⅹ ⅲ wenza i-α2-AP iboshwe ngokuhlanganyela ku-fibrin, eyenza buthaka ukuzwela kwe-fibrin ku-PL.

I-Fibrin degradation mechanism: I-PL ayingcolisi i-fibrin kuphela kodwa futhi ne-fibrinogen.I-PL yehlisa isithunzi i-fibrinogen ukuze ikhiqize izingcezu ezingu-X, Y, D kanye no-E.Ukuwohloka kwe-fibrin kubangela izingcezu ezingu-x', Y', DD, E'.Zonke lezi zingcezu zibizwa ngokuhlanganyela ngokuthi i-fibrin degradation products (FDP).

Igazi liqukethe i-fibrin, eyenziwa isebenze futhi igaywe nge-hydrolyzed ukuze ikhiqize imikhiqizo ethile ewohlokayo ebizwa ngokuthi “imikhiqizo yokuwohloka kwe-fibrin.”I-D-dimer iwumkhiqizo olula kakhulu wokuwohloka kwe-fibrin, futhi izinga elikhulayo le-D-dimer libonisa ukuba khona kwe-hypercoagulability kanye ne-hyperfibrinolysis yesibili.Ngakho-ke, i-d-dimer mass concentration ibaluleke kakhulu ekuxilongweni, ekuhlolweni kokuphumelela nasekubikezelweni kwezifo ze-thrombotic.

I-von Willebrand factor (i-antigen ehlobene ne-factor VIII) iyi-glycoprotein enkulu ekhona ku-plasma ne-endothelium futhi ibophezela kwamanye amaprotheni, ikakhulukazi i-factor VIII, evimbela ukuwohloka kwayo ngokushesha.Ayikho ku-von Willebrand's disease.I-Von Willebrand factor/factor VIII egxilile idlala indima ebalulekile ekwelapheni iziguli ezine-von Willebrand disease.Ingxenye ye-von Willebrand factor multimer iphumelela kakhulu ekuzuzeni ukopha.

I-von Willebrand factor (VWF) iyi-glycoprotein enkulu enamathelayo edingekayo ukuze i-platelet inamathele ku-subendothelium endaweni yokulimala komkhumbi, ukuhlangana kwe-platelet ukuze kwakhiwe ipulaki yeplatelet, kanye nokuzinza kwe-factor VIII (FVIII) ekuhambeni.Ukuntuleka noma ukungasebenzi kahle kwe-VWF kuholela ku-von Willebrand disease (VWD).Ukuxilongwa okunembile nokuhlukaniswa kwezinhlamvu ze-VWD kudinga iphaneli yokuhlola, okuhlanganisa i-VWF antigen, isilinganiso somsebenzi we-VWF, umsebenzi we-FVIII, izixuku ze-VWF, nezilinganiso zokubopha ze-VWF.

Ukulandelana kwezifunda ezithile ze-VWF nakho kungase kube usizo ekuxilongweni.Thayipha 1 (ukukhubazeka komthamo), uhlobo 2 (ukukhubazeka kwekhwalithi), kanye nohlobo 3 (ukuntuleka okuphelele) kufanele

zihlukaniswe ukuze zinikeze ukwelashwa okufanele.


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