I-Hepatic Function Chemiluminecense Immunoassay Kit

Inhloso yokuhlolwa kokusebenza kwesibindi ukuthola ukuthi isibindi sinaso yini isifo, izinga lokulimala kwesibindi nokuthola imbangela yesifo sesibindi, ukwahlulela ukubikezela kanye nokuhlonza imbangela ye-jaundice.Kunezinkomba eziningi ezihlobene nokusebenza kwesibindi, njenge-ALT, AST, Tbil, Dbil,ALP,γ-GT,CHE,TP,ALB,TBA,AMM,CG,AFU,ADA,PA,5'-NT,MAO,LAP.

I-Alanine aminotransferase, uhlobo lwe-transaminase, ivame ukusetshenziswa ekuhlolweni kokuhlolwa kwezifo zesibindi futhi iyinkomba ebucayi ebonisa ukulimala kwesibindi.Ekulimaleni okuhlukahlukene kwesibindi, i-serum (i-plasma) i-ALT ingakhula kakhulu ngaphambi kokuba kuvele izimpawu zomtholampilo (njenge-jaundice), ngokuvamile ehambisana nokuqina nokululama kwesifo.

I-AST itholakala enanini elikhulu lezicubu, njengemisipha yenhliziyo, isibindi, imisipha yamathambo nezinso.Amazinga aphezulu e-AST ahlotshaniswa nokulimala kwemisipha ye-myocardial kanye nohlaka lwamathambo, kanye nokulimala kwezicubu zesibindi.

I-AST ne-ALT yizinkomba ezibucayi zokuxilongwa kwezifo ze-hepatobiliary.

I-Bilirubin ingumkhiqizo wokuwohloka kwe-hemoglobin, lapho inani elikhulu le-hemoglobin liwohloka, lingakhuphula inani le-bilirubin ku-serum.Ukukhuphuka komtholampilo ukuze kukhuphuke inani le-bilirubin ukuphakama ukuze ubone i-virus ucansi lwe-hepatitis, i-hepatitis enobuthi, ngaphakathi kwesibindi noma ukuvimbela i-biliru ngaphandle kwesibindi, isifo se-hemolytic, i-physiology icteric esanda kuzalwa.Ukunqunywa kwenani eliphelele le-bilirubin ku-serum kungasiza ekuxilongeni isifo sesibindi kanye nokuvinjwa kwe-biliary.Amazinga aphakeme e-bilirubin eqondile, eyaziwa nangokuthi i-bilirubin ehlanganisiwe, abonisa ukukhishwa okukhubazekile kwe-bilirubin emgudwini we-biliary ngemva kokwelashwa kwe-hepatocyte.Ukuzimisela okuqondile kwe-bilirubin kuyasiza ekuxilongeni nasekuxilongeni okuhlukile kwezinhlobo ze-jaundice.

Ukunqunywa kwe-ALP kusetshenziselwa ikakhulukazi ukuxilongwa kokuhlolwa kwezifo ze-hepatobiliary kanye nezifo ezihlobene ne-bone metabolism.I-Serum ALP ikhuphuke kancane yaba ngokulinganisela ku-hepatitis eyingozi (igciwane kanye nobuthi), ikakhulukazi ku-cholestasis ebangelwa i-cirrhosis ne-cholelithiasis, futhi ngokuphawulekayo ekuvinjweni kwe-extrahepatic biliary tract, futhi izinga lokuphakama ngokuvamile lihlotshaniswa kahle nezinga lokuvinjelwa.

I-γ -glutamyl transferase igcwele izinso, amanyikwe, isibindi nezinye izitho, ebandakanyeka kakhulu ku-protein metabolism emzimbeni.Kuyinkomba ye-biochemical yomtholampilo ebaluleke kakhulu ekuxilongeni nasekulapheni izifo zesibindi/biliary system kanye ne-alcohol hepatitis.

Emtholampilo, ukuzimisela komsebenzi we-serum cholinesterase kuyindlela ebalulekile yokusiza ukuxilonga ubuthi be-organophosphorus nokuhlola umonakalo omkhulu wesibindi.

Ingqikithi yamaprotheni iqukethe i-albumin ne-globulin.Ukuncipha kokuqukethwe kwamaprotheni kubonwa nge-proteinemia ephansi, kufaka phakathi ukuqubuka kwe-edema kanye nomgodi womzimba unqwabelanisa uketshezi, ukonakala kokwenziwa, ukungondleki kahle, amaprotheni adonswa isithiyo sokulinda wonke umuntu angabangela i-proteinemia ephansi.

I-albumin, eyaziwa nangokuthi i-albumin, ikhiqizwa amangqamuzana e-parenchymal esibindi futhi iyiphrotheni eningi kakhulu ku-plasma.I-Alb ingagcina i-plasma colloid osmotic pressure futhi iyiphrotheni ebophayo nehambisa izinto eziningi ezibalulekile kuplasma.Ukunqunywa kwenani le-albumin kuyasiza ekuxilongeni nasekuqaphelweni kwezifo zesibindi njenge-cirrhosis.Ngaphezu kwalokho, kungabuye kubonise isimo sezempilo kanye nokudla okunempilo komuntu ngamunye, ngakho-ke kungasetshenziswa ekuxilongeni ukungondleki kanye nokuhlolwa kokubikezelwa kweziguli esezikhulile ezibhedlela.

Ukukhiqizwa kanye ne-metabolism ye-bile acid kuhlobene kakhulu nesibindi.Izinga le-serum bile acid liyinkomba ebalulekile yokulimala kwesibindi se-parenchymal, ikakhulukazi izinguquko ezibucayi ku-hepatitis eyingozi, i-hepatitis engapheli esebenzayo, ukulimala kwesibindi se-ethanol kanye ne-cirrhosis.

I-ammonia iyi-metabolite evamile emzimbeni.Ivela ekukhiqizeni i-ammonia emathunjini, ukukhishwa kwe-ammonia yezinso, ukukhiqizwa kwe-muscle ammonia, njll. Ukwanda kwabonakala ku-hepatic coma, i-hepatitis enzima, ukushaqeka, uremia, ubuthi be-organophosphorus, i-congenital hyperammonemia kanye ne-hyperammonemia yesikhashana yezingane.Kuncishiswe ekudleni okuphansi kwamaprotheni, i-anemia, njll.

I-Serum Cholyglycine (CG) ingenye ye-conjugated cholic acid eyakhiwe yinhlanganisela ye-cholic acid ne-glycine.I-Glycholic acid iyisakhi esibaluleke kakhulu se-bile acid ku-serum phakathi ne-trimester yesithathu yokukhulelwa.Lapho amangqamuzana esibindi alimala, amandla abo okuthatha i-CG ayancipha, okuholela ekukhuphukeni kwamazinga e-CG egazini.

I-α -L-fucoidase iyi-enzyme ye-lysosomal acid hydrolytic, etholakala kabanzi kumangqamuzana ezicubu zomuntu, igazi kanye noketshezi lomzimba, ohilelekile ekusetshenzisweni kwe-glycoprotein, i-glycolipids nama-oligosaccharides.Ingenye yezimpawu zomdlavuza wesibindi oyinhloko.

I-Serum ADA yanda ezifweni zesibindi futhi evamile ku-jaundice evimbelayo, ngakho-ke kungase kusize ukukhomba i-jaundice ngokuhlanganiswa nezinye izinkomba zokusebenza kwesibindi.

I-Prealbumin iyi-serum glycoprotein ehlanganiswe namaseli esibindi.

I-PA ibandakanyeka ekuthuthweni kwe-thyroxine ne-retinol ku-serum.Ngenxa yokuthi uhhafu wempilo mfushane kakhulu, isetshenziselwa ukubuka inkomba yokuxilongwa kusenesikhathi yokusebenza kwesibindi esikhubazekile kanye nokuntuleka kokudla okunomsoco, futhi iyiphrotheni ebucayi yesigaba esibi esibucayi.

I-5′ -nucleotidase (5 '-NT) iwuhlobo lwe-nucleotide hydrolyase, etholakala kabanzi ezicutshini zomuntu.I-Serum 5-NT ikhuphuke kakhulu ku-jaundice evimbelayo.Izinguquko zeSerum 5-NT ngokuvamile zihambisana ne-ALP, kodwa azihlotshaniswa nezifo zamathambo.

I-Monoamine oxidase ihileleke ekukhiqizeni imicu ye-collagen, ngakho-ke ivame ukuphakama kwezinye izifo ze-fibrotic.Ukunqunywa komsebenzi we-enzyme ku-serum kungabonisa umsebenzi wayo ezicutshini ezixhumeneyo ukuze kuqondwe izinga le-tissue fibrosis.I-LAP iyi-protease egcwele esibindini.

Umsebenzi we-LAP wanda kakhulu nge-intrahepatic kanye ne-intrahepatic biliary stasis, ikakhulukazi ku-biliary stasis eyingozi, futhi waqhubeka nokwanda ngokuqhubekayo kwesifo.I-reagent ibalulekile ekuxilongweni kwe-hepatic obstruction kanye nomdlavuza we-pancreatic.