I-Hormone Chemiluminecense Immunoassay Kit

Amahomoni ocansi adlala indima ebaluleke kakhulu ekuxhumaniseni imisebenzi evamile yokuphila komzimba womuntu.Ukuhlolwa kwama-hormone ocansi kungasetshenziselwa ukungazali, ukungasebenzi kahle kwe-axis ye-hypothalamic-pituitary-gonadal, i-polycystic ovary syndrome, i-Down syndrome, izimila zesistimu yokuzala kanye nezinye izifo zokuhlola kanye nokubikezela.

I-follicle-stimulating hormone (FSH) ne-luteinizing hormone (LH) ikhiqizwa indlala yangaphambili ye-pituitary.I-follicle-stimulating hormone (FSH) ingeyomndeni ofanayo we-gonadotropins njenge-luteinizing hormone (LH), futhi ilawula ngokuhlanganyela futhi ikhuthaze ukuthuthukiswa nokusebenza kwama-gonads (amaqanda namasende).Kwabesifazane, i-FSH isebenza ku-hypothalamic-pituitary-ovarian loop yokulawula, ikhuthaza ukwakheka kwe-ovarian estrogen ukulawula umjikelezo wokuya esikhathini.Ukukhululwa kwe-paroxysmal kwe-FSH ne-LH kusuka ku-pituitary gonadotropin kulawulwa impendulo engeyinhle yamahomoni e-steroid.Amazinga e-FSH abonisa inani eliphakeme phakathi nomjikelezo wokuya esikhathini, kodwa hhayi ngendlela ephinyiselwe njenge-LH;ngenxa yezinguquko ekusebenzeni kwesibeletho kanye namazinga e-estrogen Ukwehla, ukuya esikhathini i-FSH ifinyelela emazingeni aphezulu.I-FSH emadodeni yenza ukuthuthukiswa kwe-spermatogonia.

I-Testosterone (T) ihlanganiswa ngokuyinhloko ngamaseli e-Leydig ku-testis yesilisa, futhi iphinde ikhishwe ngamanani amancane yizindlala ze-adrenal nama-ovaries wesifazane.Ngaphezu kwama-98% e-testosterone ahlanganiswe ne-albumin kanye nephrotheni ebopha amahomoni ocansi ngemva kokungena egazini, kanti inani elincane (2%) likhona ngendlela yamahhala (FT).I-testosterone ehlanganisiwe (i-Alb-T) ayisebenzi ngokwezinto eziphilayo futhi ihlukaniseka kalula kumbhede we-capillary wezicubu, ikhiphe i-T ukuze isetshenziswe izicubu.I-Alb-T kanye ne-FT ngokuhlangene kubizwa ngokuthi i-testosterone etholakalayo.Kwabesilisa, umsebenzi oyinhloko we-testosterone ukukhuthaza nokugcina ukuthuthukiswa kwezici zobulili zesibili zesilisa, ukugcina umsebenzi wezocansi wesilisa, ukukhuthaza ukuhlanganiswa kwamaprotheni kanye nokukhula komnkantsha wamathambo, nokwandisa i-basal metabolism.Ngaphezu kwalokho, i-testosterone, kanye ne-LH, ikhuthaza ukwakheka nokuvuthwa kwesidoda, futhi ihlotshaniswa ne-sperm motility kanye ne-seminiferous tubule metabolism.Kwabesifazane, i-testosterone idlala indima ebalulekile ekugcineni ukukhula nokuthuthuka okujwayelekile kanye nokulawulwa okuthile kwe-metabolic ngesikhathi sokuthomba kwabesifazane.

I-Dehydroepiandrosterone (DHEA) iwuphawu lomsebenzi we-androgenic wezindlala ze-adrenal.Iningi layo lisesimweni se-sulfate (DHEAS), eguqulwa isuka ku-DHEA ngesenzo se-enzymatic ku-adrenal gland, futhi iyisandulela sokuhlanganiswa kwe-testosterone ne-estrogen.I-Androstenedione ikhiqizwa ama-gonads wesilisa nama-ovari wesifazane, kanye nezindlala ze-adrenal kwabesilisa nabesifazane.Yisandulela se-testosterone ne-estrogen.Emadodeni, i-androstenedione iguqulwa ibe yi-testosterone isebenzisa i-17β-hydroxydehydrogenase.Kwabesifazane, i-androstenedione iguqulelwa ku-estrogen kusetshenziswa i-aromatase.

I-Estradiol (E2) ingenye ye-estrogen esebenza kakhulu yezinto eziphilayo, ikakhulukazi ekhishwa ama-ovaries, futhi iphinde ikhishwe ngamanani amancane yizindlala ze-adrenal kanye namasende wesilisa.U-98% wegazi elijikelezayo uboshelwe ku-albumin ne-SHBG, futhi inani elincane kuphela elikhona esimweni esikhululekile.I-E2 ikakhulukazi ikhuthaza ukukhula kwe-epithelium yokuzala yabesifazane, isifuba, isibeletho, amathambo amade kanye nokuthuthukiswa kwezici zobulili zesibili, ibamba iqhaza ku-lipid metabolism, ilawula imisebenzi eminingi yamangqamuzana e-vascular smooth muscle namaseli e-endothelial, futhi idlala indima ebalulekile endleleni yokulawula. nge-ovulation.

I-progesterone (i-Prog) ihlanganiswa ngokuyinhloko ngamaseli e-luteal kanye ne-placenta ngesikhathi sokukhulelwa, futhi iyisandulela se-testosterone, i-estrogen kanye namahomoni e-adrenal cortex.Izinga leprogesterone elikhiqizwa amadoda nabesifazane abavamile liphansi kakhulu, futhi ngemva kokuphuma egazini, liboshelwe ikakhulukazi ku-albumin kanye neprotheni ebopha amahomoni ocansi futhi izungeza emzimbeni.Amazinga e-progesterone ahlotshaniswa nokuthuthukiswa kanye ne-atrophy ye-corpus luteum, kodwa amazinga e-progesterone egazini aphansi ngesikhathi sokuvuthwa kweqanda emjikelezweni wokuya esikhathini kowesifazane.Amazinga aphakeme e-progesterone angabonwa ngosuku olwandulela i-ovulation, futhi ukwakheka kwe-progesterone kukhula kakhulu phakathi nesigaba se-luteal.Phakathi nomjikelezo wokuya esikhathini, indima eyinhloko ye-progesterone ukukhuthaza ukuqina kwe-endometrium, okubangela ukuthi imithambo yegazi kanye nezindlala zande, okubangela ukukhishwa ukuze kube lula Ukufakwa kweqanda elivundisiwe (umbungu).Ngesikhathi sokukhulelwa, i-progesterone igcina ukukhulelwa futhi ivimbela ukufinyela kwe-myometrial.I-progesterone ingakwazi futhi ukusebenza ku-mammary gland ukuze ikhuthaze ukuthuthukiswa kwe-mammary acini kanye nemigudu yokulungiselela ukuncelisa.

I-17α-hydroxyprogesterone (17α-OHP) iguqulwa yi-progesterone ngaphansi kwesenzo se-17α-hydroxylase, noma nge-17α-hydroxypregnenolone ngaphansi kwesenzo se-3β-hydroxysteroid dehydrogenase, ekhiqizwa yi-adrenal cortex ne-gonads, umsebenzi wayo we-progesterone uphansi kakhulu.I-17α-OHP iwu-21-hydroxylated ukuze yakhe inhlanganisela ye-precursor S ye-cortisol.I-17α-OHP ku-serum ikakhulukazi isebenza namahomoni ocansi ukukhuthaza ukuthuthukiswa kwezitho zomuntu ngamunye.

I-Sex hormone-binding globulin (SHBG) iphrotheni ehambisa i-testosterone ne-estrogen (E2) egazini.I-SHBG ikhiqizwa ngokuyinhloko isibindi, futhi ukuhlanganiswa kwayo kanye nokukhishwa kwayo kulawulwa yi-estrogen futhi kuthinteke kabi okuqukethwe kwamafutha e-hepatic kanye nama-cytokines avuthayo.Ukuhlushwa kwe-Serum SHBG kuhlobana namazinga e-hormone, ukusebenza kwesibindi, nokuvuvukala.

I-Prolactin (PRL) ivalwa amangqamuzana e-adeno-pituitary futhi ingakhuthaza ukukhula, ukuthuthukiswa kanye nokuhlukaniswa kwesitho sayo esihlosiwe sezicubu ze-mammary gland, futhi iyisimo esibalulekile ekukhuleni kwebele okujwayelekile kanye nokuncelisa kwabesifazane.Ngokubamba iqhaza kwe-estrogen, i-progesterone, i-glucocorticoid ne-insulin, i-PRL ingakhuthaza ukuvuthwa kwama-mammary vesicles kanye nokukhishwa kobisi, futhi ibambe iqhaza ekugcineni ukukhishwa kobisi ngesikhathi sokuncelisa.Uma ukuncelisa kungasetshenziswa, amazinga e-PRL abuyela kwesijwayelekile phakathi namasonto amathathu ngemva kokubeletha.Lapho kukhona i-testosterone, i-PRL ingakhuthaza ukuthuthukiswa kwe-prostate wesilisa kanye nama-seminal vesicles, futhi ithuthukise umphumela we-LH kumaseli e-Leydig ukwandisa ukuhlanganiswa kwe-testosterone.Ngaphezu kwalokho, i-PRL nayo inemisebenzi yokulawula ukukhiqizwa kwe-adrenal ye-androgens nokubamba iqhaza ekuphenduleni ukucindezeleka.

I-chorionic gonadotropin yomuntu (HCG) iyihomoni ye-glycoprotein ekhiqizwa ikakhulukazi amaseli e-placental trophoblast.Umsebenzi oyinhloko we-HCG ukukhuthaza ukuguqulwa kwe-ovarian corpus luteum ibe yi-corpus luteum yokukhulelwa, ukulawula ukuhlanganiswa kwamahomoni e-steroid, nokuvimbela umbungu ofakwe iqanda elivundisiwe ukuba unganqatshwa.Ekuqaleni kokukhulelwa, igazi likamama kanye nomchamo we-HCG lingakhula ngokushesha, futhi kancane kancane likhule ngokuqhubeka kokukhulelwa, lifinyelele phezulu emavikini angu-8-10, futhi kancane kancane liyehla ngemva kwezinyanga ezintathu zokuqala.

Ihomoni ye-Mullerian (AMH), ilungu le-beta superfamily eshintshayo yokukhula, idlala indima ebalulekile ekuthuthukisweni kwezitho ze-gonadal futhi ingenye yezimpawu ezibalulekile zokusebenza kwe-gonadal yabesilisa nabesifazane.Kwabesilisa, i-AMH ikhiqizwa ikakhulukazi amaseli e-Leydig, aqala nge-embryogenesis futhi aqhubeke kukho konke ukuphila;ekukhuleni kombungu wesilisa, i-AMH ibangela ukonakala komgudu we-Mullerian ukuze kwakheke umgudu wokuzala wabesilisa ovame ukukhula.Kwabesifazane, i-AMH ikhiqizwa ikakhulukazi amangqamuzana e-ovarian granulosa, anamazinga aphezulu aqala ekuthombeni, bese ehla kancane ngokukhula futhi acishe angabonakali ngemva kokunqamuka kokuya esikhathini.

I-Inhibin B (INHB) iyi-dimeric glycoprotein, ilungu le-β-transforming growth factor superfamily, ehilelekile ekulawulweni kwe-testicular spermatogenesis, ukuthuthukiswa kweqanda, ukuvuthwa, kanye ne-ovulation, futhi iyi-cytokine ehlobene eduze nemiphumela yokukhulelwa.Kwabesilisa, izinga le-INHB egazini kanye ne-seminal plasma lingabonisa umsebenzi we-spermatogenic we-testis futhi lihlobene eduze nokuzala kwabesilisa.Kwabesifazane, amazinga e-INHB egazi nawo ahlotshaniswa eduze ne-endometriosis, i-polycystic ovary syndrome (PCOS), kanye ne-ovarian hyperstimulation syndrome (OHSS).

I-estriol yamahhala (uE3) ngokuyinhloko i-estriol ekhishwa isibindi se-fetus ne-placenta.Ingene egazini likamama nele-fetus ngendlela ekhululekile.Iphrotheni ye-plasma ehlobene nokukhulelwa A (PAPP-A) iyi-macromolecular glycoprotein ekhiqizwa kakhulu yi-placenta ne-decidua.Ngesikhathi sokukhulelwa, i-PAPP-A ikhiqizwa ngobuningi be-decidua futhi ikhishwe ekujikelezeni kukamama, lapho ukugxila kwe-PAPP-A kwanda ngokukhula okukhulayo kuze kube sekubelethweni.I-beta-human chorionic gonadotropin yamahhala (yamahhala-β-HCG) iyiyunithi ye-beta ye-HCG.I-uE3, i-PAPP-A, i-free-β-HCG ibaluleke kakhulu ekuhlolweni kokubeletha ukuze kuhlolwe i-Down syndrome nokunye okungavamile kwe-chromosomal ku-trimester yokuqala neyesibili.