I-Immunoglobulin Chemiluminecense Immunoassay Kit

I-Autoimmune hepatitis (AIH) yisifo sesibindi esivuthayo esingapheli, esibonakala ngokuphakama kwama-aminotransferase, ukuba khona kwe-anti-nuclear antibody noma i-anti-smooth muscle antibody, i-immunoglobulin G (IgG) ephakeme, kanye nokuvuvukala kwe-hepatitis/plasma-lymphocytic okusekelwe emlandweni. .Ucwaningo lwakamuva lwe-epidemiological lubonise umkhuba okhulayo wokusabalala kwe-AIH emhlabeni wonke, ikakhulukazi ezigulini zesilisa;lokhu kuthambekela kungase kusikisele ukuguqulwa kwezimbangela zemvelo zezifo eziqala ngokuhamba kwesikhathi.Njengoba kungekho uphawu lwebhayoloji oluqondene nesifo esithile noma ukutholwa kwe-histological okutholakalayo njengamanje, i-AIH idinga ukuxilongwa komtholampilo, futhi kuhlongozwe uhlelo lokufaka amaphuzu okuxilonga oluqinisekisiwe olunokucaciswa okwamukelekayo nokuzwela kuye kwahlongozwa.Ngokuphathelene nokwelashwa, kunconywa i-corticosteroids ne-azathioprine, futhi kulabo ababonisa impendulo engaphelele noma labo abangabekezeleli le mithi, ukwelashwa komugqa wesibili, njenge-mycophenolate mofetil, kucatshangelwa.Sekukonke, umphumela wesikhathi eside muhle kakhulu ezigulini ezinezimpendulo eziphelele ze-biochemical, kuyilapho ukwelashwa kwesondlo impilo yonke kungase kudingeke njengoba ukumiswa kwama-immunosuppressive agents kuvame ukuholela ekubuyeleni kwesifo.I-AIH ye-Acute-start iyenzeka, futhi ukuxilongwa kuyinselele kakhulu ngenxa yokuntuleka kwe-serum autoantibodies noma i-IgG ephakeme.Izidingo ezingakafinyelelwa zibandakanya ukuxilonga kusenesikhathi, ukungenelela ngeziqondiso zokwelashwa ezisatshalaliswayo, nokuqashelwa kanye nokwenza ngcono izinga lempilo leziguli elihlobene nempilo ngokuthuthukiswa kwemithi yokwelapha yamahhala ye-corticosteroid.I-Immunoglobulin G ingukuqukethwe okuphezulu kakhulu kwe-immunoglobulin ku-serum, ibalwa ku-75-80% yenani eliphelele.Kubantu abanempilo, i-IgG ingahlukaniswa ngama-subtypes amane: i-IgG1-IgG4, lapho i-IgG4 ingavamile ukuvezwa futhi ilandisa kuphela ku-1-7%.Ukuhlobana kwayo okuphansi kwe-antigen eqondiwe akukwazi ukwenza kusebenze umphelelisi, kodwa kungavimbela ukwakheka kwama-immune complexes amanye ama-subtypes.