Ikhithi Yokuhlola Isifo Se-Interstitial Lung(ILD).

Izifo zamaphaphu e-interstitial ziyiqembu lezinkinga zamaphaphu ezihlakazekayo ezihambisana nokugula nokufa.Ulwazi oluzuzwe eminyakeni yamuva luye lwaphumela ekushicilelweni kwesigaba esisha se-idiopathic interstitial pneumonias, ngokusho ukuthi kukhona amaqembu amathathu: amakhulu, angavamile futhi angahlukaniswanga.Ubusha bokuhlukaniswa ngezigaba buvela eqinisweni lokuthi okunzima ukuhlukanisa izinhlangano zingelashwa ngokuya ngezigaba zokuziphatha kwesifo.I-Idiopathic pulmonary fibrosis iyingozi kakhulu phakathi kwezifo zamaphaphu ahlanganayo futhi iveza ukuhlukahluka okukhulu ekuziphatheni komtholampilo.Kuphakanyiswe ama-biomarker amaningi ukuze kubikezelwe ukuthi lesi sifo sizohamba kanjani kanye neziguli ezinezimpawu ezifanayo ezivivinyweni zomtholampilo.Ukuxilongwa kusenesikhathi kanye nokuhlukaniswa kwezifo nakho kubalulekile emkhakheni wezinye izifo zamaphaphu ahlanganayo.I-Krebs von den Lungen-6 (KL-6) iwuhlobo lwe-transmembrane mucin equkethe iketango likashukela one-asidi yamathe, enesisindo sengqamuzana esingu-200 KD.I-KL-6 iboniswa ikakhulukazi ohlotsheni Ⅱ amaseli e-alveolar, noma i-cytoplasm kanye nolwelwesi lweseli lwamaseli e-bronchial epithelial.Ingxenye yenkulumo yenzeke ku-bronchioles basal cell kanye ne-Clara cell cytoplasm noma izindlala ze-bronchial, pancreas, isisu, amaseli e-epithelial egland yebele wenhlangano yesitho, njll. I-KL-6 inomthelela oqinile we-chemotaxis kuma-fibroblasts futhi ikhuthaza ukwanda nokufuduka kwama-fibroblasts. , eqondisa ukuthuthukiswa kwe-pathological tissue fibrosis.I-KL-6 ingakhuthaza ukwanda kwama-fibroblasts wamaphaphu omuntu futhi ivimbele i-apoptosis yawo.Eminyakeni yamuva nje, ucwaningo oluningi luye lwathola ukuthi inkulumo ye-KL-6 ihlotshaniswa nezimila, ezinye izifo zamaphaphu ezisanda kuzalwa, i-ILD kanye nokuwohloka kwayo, ukulimala okukhulu kwamaphaphu nezinye izifo.Njengenkomba yokubhujiswa kwe-alveolar epithelial cell kanye nokuvuselelwa, i-KL-6 isetshenziselwa ukutholwa okusheshayo, okulula, ukonga, okuphindaphindayo nokungahlaseli, okuphakeme kunezindlela zakudala ezifana ne-high-resolution lung CT, i-alveolar lavage kanye ne-lung biopsy.Izinga le-KL-6 ku-serum yesiguli lingathathwa njengenkomba yokuvimbela kusenesikhathi isifo samaphaphu.