Ikhithi Yokuhlola I-Membranous Nephropathy(MN).
| Isixazululo se-Chemiluminescent (i-Autoimmune Diseases) | ||
| Uchungechunge | Igama Lomkhiqizo | Abbr |
| I-Membranous Nephropathy | I-Anti-Phospholipase A2 Receptor Antibody | I-PLA2R |
| I-Anti-C1q Antibody | C1q | |
| I-Anti-thrombospondin Type I Domain Equkethe I-7A Antibody | I-THSD7A | |
I-Membranous nephropathy (MN) iveza njengesifo esiqondene nesitho esithile sokuzivikela komzimba.I-Phospholipase A2 receptors (PLA2R), eyingxenye ye-transmembrane receptor yohlobo lwe-I, ivezwa nge-glomerular cell surface.Ezigulini ezine-nephropathy ye-membranous ene-phospholipase A2 receptor anti-positive, i-anti-phospholipase A2 receptor antibody ejikelezayo kanye ne-antigen kuya ku-phospholipase A2 receptors ihlangana njenge-immune complex, idiphozi kulwelwesi olungaphansi lwe-glomerular, yenza kusebenze uhlelo oluhambisanayo olugcina lulimaza iseli le-Sertoli I-glomerular filtration barrier futhi ibangela amaprotheni omchamo.Izinga le-PLA2R lihlobene eduze nomsebenzi womtholampilo, okuyinkomba enhle yokubikezela inqubo yesifo.Ukuhlaziywa kwabonisa ukuthi izinga le-serum PLA2R lalinokuzwela okungama-73% kanye nokucaciswa okungama-83% ekuxilongweni kwe-nephropathy esebenzayo ye-idiopathic membranous, okubonisa ukuthi izinga le-PLA2R le-serum linenani lokuxilonga esigabeni esisebenzayo se-idiopathic membranous nephropathy.
I-C1q iyingxenye yomphelelisi 1(C1), umqalisi wendlela yakudala yokuhambisana nokuzivikela komzimba okungaphakathi.I-C1q isebenza njengeyunithi yokuqala yokusabela yengxenye yokuqala yomphelelisi C1.Ibophezela kuma-antigen-antibody immune-complexes, ibamba iqhaza ezindleleni ze-classical complement activation kanye nama-molecule e-C1r kanye ne-C1s, futhi ilamula ukucaciswa kwezinto ezithathelwanayo, imikhiqizo ye-apoptotic kanye ne-immune complexes ohlelweni lwe-mononuclear macrophage.Uma amasosha omzimba e-anti-C1Q ekhona, azonciphisa ukucaciswa kwe-immune complex kanye namaseli e-apoptotic, akhuthaze amasosha omzimba ukuthi akhiqize amasosha omzimba amaningi, okuyisici esiholela ekusebenzeni kwesifo (systemic lupus erythematosus).
Uhlobo Ⅰ isizinda se-platelet reactive protein 7A (THSD7A) kungenye i-podocyte antigen ebangela i-MN ngemva kwe-phospholipase A2 receptor (PLA2R).Ukutholakala kwe-THSD7A kanye nezivikelamzimba zayo kuholele ekuqondeni okusha kwe-MN.I-antibody ye-Serum THSD7A ingabophezela ku-podocyte THSD7A antigen yakhe i-situ immune complex, okuholela ekulimaleni kwe-podocyte kanye ne-proteinuria.Ngokufana ne-antibody ye-PLA2R, i-antibody ye-THSD7A ingasetshenziswa ukuqondisa ukuxilonga, ukubikezela kanye nokuqapha izifo ze-MN.
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