Enye Ikhithi Yokuhlola I-Anticoagulant, i-C-Luminary Biotechnology

I-Lupus anticoagulant iyi-autoantibody emelene ne-phospholipids enecala elibi, uhlobo lwe-antiphospholipid antibody, evame ukutholakala ezigulini ezinezifo ezixhumene nezicubu ezifana ne-systemic lupus erythematosus.Ngenxa yokuthi yafundwa okokuqala ezigulini ezine-lupus erythematosus, yaqanjwa ngokuthi i-lupus anticoagulant.Kuye kwatholakala ukuthi ikhona ezifweni ezihlukahlukene.Ukuphikelela kwezinto ze-lupus anticoagulant kuthathwa njengefulegi elibomvu lokuphuphuma kwesisu okuphindaphindekayo okungachazwanga, ukuzala umntwana oshonile, ukukhubazeka komntwana, i-arteriovenous thrombosis, izifo ezihlukahlukene ze-thrombophilic, nezifo ezithile ezizimele.I-Lupus anticoagulant (LAC) iyi-immunoglobulin, i-IgG I-IgM noma inhlanganisela yakho kokubili.Umsebenzi wayo wokuzivikela komzimba utholakala ngokuyinhloko ku-IgM, futhi iyi-antiphospholipid antibody (okuhlanganisa i-anticardiolipin Lapho i-prothrombin iguqulwa ibe i-thrombin, idinga ukuqukatha i-activator ye-prothrombin eyakhiwe ama-phospholipids, izici ze-coagulation V, X, Ca2+, njll., futhi i-LAC iyinkimbinkimbi Phakathi kwama-phospholipids, ibophezela kuma-phospholipid futhi yenza ama-phospholipids angasebenzi, kwandise ukuguqulwa kwe-prothrombin ibe i-thrombin Ngakho-ke, kungase kufaneleke kakhulu ukuyibiza ngokuthi i-anti-prothrombin antibody, futhi ukutholwa kokuhlola kwezinto ze-lupus anticoagulant kungase kufaneleka kakhulu.

Ukuxilongwa kwezifo eminyangweni ehlukahlukene yezokwelapha kubaluleke kakhulu

I-Antithrombin III (i-antithrombin, i-AT III) ingenye yezinto ezibalulekile ze-anticoagulant emzimbeni womuntu.I-glycoprotein enesisindo samangqamuzana esihlobene esingaba ngu-58.2kD ekhishwa ama-hepatocytes, futhi iyi-serine protease inhibitor.Ngokuvimbela umsebenzi we-thrombin kanye ne-activated coagulation factor VIIa, IX, X, XI kanye ne-XII serine proteases, igcina ibhalansi ye-coagulation yegazi emzimbeni, futhi indima yayo ilandisa cishe u-70% wengqikithi yomsebenzi we-anticoagulation system.I-Heparin ingadala ushintsho lokuvumelana ku-antithrombin, okwenza kube lula ukuthi i-thrombin ibophe, okungathuthukisa kakhulu umphumela we-anticoagulant we-antithrombin.

Ukuntuleka kwe-AT okutholiwe kuyimbangela evamile ye-venous thrombosis kanye ne-pulmonary embolism

Ukuntuleka kwe-AT ye-Hereditary kuyisifo se-autosomal esivelele sofuzo, ukusabalala kwalesi sifo cishe ku-1/5000, isigameko ngokuvamile sineminyaka engu-10-25 ubudala, futhi iziguli zivame ukuthuthukisa imithambo ngemva kokuhlinzwa, ukuhlukumezeka, ukutheleleka, ukukhulelwa noma ukubeletha.I-Thrombosis, engase iphinde ivele

Ukwenyuka komsebenzi we-AT III kubonakala ezikhathini zokopha okukhulu njenge-hemophilia, i-leukemia, ne-aplastic anemia, kanye nokwelashwa kwama-anticoagulants omlomo.Ekwelashweni kwe-anticoagulation, uma kusolwa ukumelana nokwelashwa kwe-heparin, ukutholwa komsebenzi we-AT III kungasetshenziswa ukunquma.Ukuhlolwa kwe-AT III kufanele futhi kunconywe ukuze kuqashwe ngesikhathi sokwelashwa esikhundleni se-antithrombin kanye nokuqapha umphumela we-anticoagulant we-heparin.