I-Pemphigus Chemiluminecense Immunoassay Kit

I-Pemphigus iyiqembu lezilonda zesikhumba ezizimele ezibandakanya isikhumba nolwelwesi lwamafinyila.Ngaphansi kwezici ezihlukahlukene ze-pathogenic futhi umzimba ukhiqiza amasosha omzimba athile aqondiswe kuma-desmosomes angaphezulu kwama-keratinocytes, okuholela ekukhululweni kwama-acanthocyte.Ngokusho kokubonakaliswa komtholampilo, i-pemphigus ingahlukaniswa ngezinhlobo ezine: evamile, ekhulayo, e-defoliated kanye ne-erythematous.Ucwaningo luye lwaqinisekisa ukuthi i-desmoglein (Dsg) idlala indima ebalulekile ku-pathogenesis ye-pemphigus.I-Dsg 1 kanye ne-Dsg3 IgG amasosha omzimba aqinisekiswa njengamasosha omzimba amakhulu.Izinga lokwenzeka kwe-pempgigusvulgaris (PV) liphezulu futhi liwuhlobo oluncane olunzima kakhulu ku-pemphigus.Ukwenzeka kwe-anti-Dsgl antibody kukhombisa ukuthi ngaphandle kokwethulwa ngomlomo, kuhlanganisa nezilonda zesikhumba nolunye ulwelwesi lwamafinyila.I-PV ngokuvamile iqala emlonyeni womlomo (ama-50% kuya ku-70% amacala) futhi yenzeke ngaphambi kwezinye izilonda.Kungaba ukuphela kokubonakaliswa komtholampilo kwalesi sifo.Ngakho-ke, odokotela abahlinza ngomlomo badlala indima ebalulekile ekutholakaleni kusenesikhathi kanye nokuxilongwa kusenesikhathi kwe-PV.Ukuba khona kwe-anti Dsg1 antibody kanye ne-anti Dsg3 antibody ku-serum yeziguli ze-pemphigus kungasetshenziswa ukuze kutholwe uhlobo lwe-clinical phenotype.Amazinga e-titer amasosha omzimba amabili kanye nezinhlobo zawo ezincane angasetshenziswa ukunquma isimo nomsebenzi.Lezi zineziqondiso ezibalulekile ezibalulekile ekuxilongweni nasekulashweni kwe-pemphigus.

I-Paraneoplastic pemphigus (PNP) isifo esitholwa yinkunzi esihlotshaniswa ne-autoimmunity.Isethulo somtholampilo sethulwe ngokulimala kwezitho eziningi.Izimpawu ezivame kakhulu yi-refractory stomatitis, ukuguguleka, izilonda, ukopha kwe-mucosa yomlomo nezindebe.I-pathogenesis ye-PNP ayichazwanga kahle.I-IP iqinisekise ukuthi ama-autoantibodies ku-sera yesiguli abona ama-antigen e-epidermal intracytoplasmic desmoplakin (umndeni we-plakin).Ucwaningo luqinisekisile ukuthi i-anti Dsg3 antibody idlala indima ebalulekile ku-acantholysis kanye nokwakheka kwamabhamuza kwama-PNP ekuhlolweni kokudlulisa okungenzi lutho.

I-Bullous pemphigoid (BP) yisifo sesikhumba esizimele, esivame ukubonakala kubantu abadala abangaphezu kweminyaka engama-60 ubudala.I-antigen eyinhloko ye-pathogenic ye-BP i-cutaneous half desmosomes futhi izingxenye zayo eziyinhloko ziyi-bullous pemphigoid antigen (BPAGl, BP230) ne-bullous pemphigoid antigen 2 (BPAG2, BPl80, uhlobo lwe-cartilage collagen).Ukutholwa kwe-anti-BPl80 ethize yokulwa ne-antibody kunokuzwela okuphezulu nokucacisa, okungasetshenziswa njengenkomba ebalulekile yokuqondisa umkhuba womtholampilo.