Izifo ezingezwani nomzimba yizimo lapho isiguli sihogela khona noma sidle izinto eziqukethe izakhi ezingezwani nomzimba (okuthiwa izinto ezingezwani nomzimba noma izinto ezingezwani nomzimba, izinto ezingezwani nomzimba) ezibangela amaseli B omzimba ukuthi akhiqize i-immunoglobulin E (IgE) eyeqile.Ukutholwa kwe-IgE isiyonke kungasetshenziswa ukusiza ekuxilongweni kwesifuba somoya esingezwani nomzimba, i-rhinitis yokungezwani nenkathi yonyaka, i-atopic dermatitis, inyumoniya ye-interstitial ebangelwa izidakamizwa, i-bronchopulmonary aspergillosis, uchoko, i-pemphigoid kanye nezifo ezithile ezinamagciwane.
