Amaprotheni C System Chemiluminecense Immunoassay Kit

Uhlelo lwe-protein C luhlanganisa ikakhulukazi amaprotheni C (PC), amaprotheni S (PS), i-thrombomodulin (thrombomodulin, TM, eyaziwa nangokuthi i-thrombomodulin ne-protein C inhibitor).I-PC yenza i-protein C ecushiwe (APC) ngaphansi kwesenzo se-thrombin, engakwazi ikakhulukazi ukuvala ama-coagulation cofactors i-FVa ne-Fla;vimbela ukuboshwa kwe-factor Xa kuma-platelet;ukuthuthukisa i-fibrinolysis;I-PS idlala kakhulu indima yayo ngokusheshisa ukungasebenzi kwe-Fla nge-APC Function;I-TM igxilile kulwelwesi lweseli futhi empeleni iyisamukeli se-thrombin.Ebukhoneni be-Ca2+, isheshisa ukwenziwa kusebenze kwe-PC .

I-activated protein C (APC) isebenza njenge-anticoagulant "efunwayo", inciphisa ukwakheka kwe-thrombin.Amazinga e-plasma ancishisiwe we-APC noma amaprotheni C (PC) ahlotshaniswa nengozi eyengeziwe ye-venous thromboembolism.I-APC iphinde ibonise imisebenzi ye-cytoprotective kanye nokusetshenziswa kwayo kokwelapha kuye kwahlolwa ku-sepsis enzima futhi ingaphansi kokuhlolwa kwezifo eziningana ezinengxenye ebalulekile yokuvuvukala.

I-activated protein C (APC) iyi-serine protease etholakala kumanduleli wayo angasebenzi, iphrotheni C (PC), esebenza njenge-anticoagulant yemvelo enamandla ngezinto ezingasebenzi u-Va no-VIIIa.Isizukulwane se-APC esijwayelekile sincike ekuhlanganisweni okunembile kwe-thrombin, i-thrombomodulin, i-PC kanye ne-endothelial cell PC receptor (EPCR) ebusweni bamaseli e-endothelial.Ngakho-ke, noma yiluphi ushintsho ekusebenzeni kahle kwalokhu kuhlanganisa lungabangela ukuncipha noma ukwanda kwesizukulwane se-APC esishintsha ubungozi be-thrombosis.

Kunobufakazi besizukulwane se-APC ku-vivo.Ngakho-ke, kubikwe ukuba khona kwamanani ajikelezayo e-peptide yokuvula i-PC kanye nama-complexes e-APC nama-physiological inhibitors.Ukufaneleka ngokomzimba kwe-PC ekulawuleni ukuhlangana kwegazi kuvela encazelweni yokwanda kwengozi ye-venous thromboembolism (VTE) ehambisana nakho kokubili ukuntuleka kwe-PC yofuzo kanye namazinga aphansi e-APC ajikelezayo.

Nakuba kwakusolwa ngokomqondo kuma-60s, imisebenzi yeProtein C kanye ne-Protein S ku-hemostasis yaphenywa futhi yabikwa kusukela maphakathi nawo-80s, kwalandelwa ukutholakala kwe-Thrombomodulin, i-endothelial cell membrane ehambisana neprotheni, edlala indima ebaluleke kakhulu ye-heamostatic.Lawa maprotheni angu-3 asebenza ekulawuleni i-thrombogenesis futhi avikele ezenzakalweni ze-thrombo-embolic.Lapho igazi selicushiwe, noma iyiphi i-thrombin ejikelezayo ithathwa yi-Thrombomodulin ku-microcirculation, okwenza i-thrombin ibe i-anticoagulant ngokusebenzisa amandla ayo okwenza kusebenze i-Protein C kuya ku-Actiated Protein C, esebenza njengomlindi ekuhlanganeni kwegazi, ngendlela eyinkimbinkimbi. nge-Protein S yamahhala, ukuvimba noma iyiphi indawo entsha yokusebenzisa igazi, futhi ikakhulukazi ukujikeleza okucushiwe kwe-Factors V kanye ne-VIII.I-Protein S ayisebenzi nje njenge-cofactor ye-Active Protein C, kodwa futhi njenge-cofactor ye-Tissue Factor Pathway Inhibitor.Ngaphezu kwalokho, inemisebenzi ethile endleleni yokugcwalisa ngokubophezela kwayo ku-C4b-BP.Elinye ikhono le-protein C elicushiwe ukwehlisa umsebenzi we-fibrinolytic, njengoba i-Actiated Protein C Inhibitor yaziwa nangokuthi i-Plasminogen Activator Inhibitor 3. Uhlelo lweProtein C-Protein S luba lungasebenzi kahle phambi kwe-Factor V (Factor V-Leiden noma eguquliwe). ezinye izinhlobo), ezimelana nomphumela wazo wokungasebenzi.Amanye ama-pathologies axhumene nalolu hlelo athinta ukwakhiwa kwe-allo- noma i-autoantibodies ku-Protein S noma i-thrombin, engabangela izinkinga ezinzima ze-thrombotic ezigulini ezithintekile.Amaprotheni Acushiwe (ikakhulukazi ezigulini ezine-sepsis) noma i-Thrombomodulin ahlongozwa njengemithi elwa nokuvuvukala.Okubaluleke kakhulu, ukushoda kokuzalwa noma okutholiwe kwe-Protein C noma i-Protein S kuhlotshaniswa nezenzakalo ezimbi eziphindelelayo ze-thrombotic.