Ingqikithi ye-IgE Chemiluminecense Immunoassay Kit

Kunemindeni eyisihlanu ye-immunoglobulin superfamilies, i-G, M, A, D, E, i-IgE incane kakhulu, kodwa futhi uhlobo lwe-hypersensitivity esheshayo ihlobene ngokungenakuhlukaniswa.I-IgE ivamise ukuhlala phezu kwama-mast cells nama-basophil, izinto ezingezwani nezifo zingena ngaphandle, futhi i-IgE iyala ngokushesha la maseli amabili ngesamukeli se-fc.Lapho nje ama-mast cells nama-basophils ewohloka, akhulula izinto eziningi eziyinqaba njenge-histamine, kinins, leukotrienes, ne-prostaglandin D2.Lezi zinto zizoholela ochungechungeni lwe-hypersensitive pathological reactions, ezivimbela umsebenzi we-IgE, okuzonciphisa ngokuphumelelayo izinga le-hypersensitivity.

I-IgE wuhlobo lwe-immunoglobulin eyatholwa ngo-1966 enesisindo samangqamuzana esingu-188kD.Okuqukethwe kwe-IgE ku-serum kuphansi kakhulu, kubala kuphela u-0.002% wengqikithi ye-Ig ku-serum.Ikhiqizwa ngasekupheleni kwe-ontogeny.I-IgE ikhiqizwa ikakhulukazi amaseli e-plasma ku-lamina propria ye-mucosa, njenge-nasopharynx, amathoni, i-bronchi, ne-gastrointestinal tract.Lezi zingxenye zivame ukuba yizindawo lapho ukuhlasela kwe-allergen kanye nohlobo lwe-I yokungezwani komzimba kwenzeka.I-IgE iyi-cytophilic antibody, izifunda ezisebenzayo ze-Cε2 kanye ne-Cε3 zingabophezela ku-FcERI ehambisana kakhulu nolwelwesi lwama-basophil nama-mast cells.Lapho i-allergen iphinda ingena emzimbeni, ibophezela ku-IgE egxilwe kuma-basophils nama-mast cell, okungabangela ukungezwani kohlobo I.Ukutholwa kwe-IgE isiyonke kungasetshenziswa ukusiza ekuxilongweni kwesifuba somoya esingezwani nomzimba, i-rhinitis yokungezwani nenkathi yonyaka, i-atopic dermatitis, inyumoniya ye-interstitial ebangelwa izidakamizwa, i-bronchopulmonary aspergillosis, uchoko, i-pemphigoid kanye nezifo ezithile ezinamagciwane.

Izindlela ezivame ukusetshenziswa zokuthola i-IgE ephelele emtholampilo zifaka i-fluorescence immunoassay, i-enzyme-linked immunoassay (ELISA), i-chemiluminescence immunoassay (CLIA).Endabeni yokuzimisela okuphelele kwe-Ige, gwema ukudla ama-shrimp, izilwane zasolwandle nokunye ukudla okuvame ukungezwani komzimba, ukuze ungakhulisi izimpawu zokungezwani komzimba.